| Literature DB >> 11741476 |
T J Altstadt1, C R Fairchild, J Golik, K A Johnston, J F Kadow, F Y Lee, B H Long, W C Rose, D M Vyas, H Wong, M J Wu, M D Wittman.
Abstract
The preparation of C-7 paclitaxel ethers is described. Various substituted ethers were prepared via activation of the corresponding methylthiomethyl ether followed by alcohol addition. Variation of the C-7 ether group as well the 3' side chain position led to the discovery of a novel taxane, BMS-184476 (4), with preclinical antitumor activity superior to paclitaxel.Entities:
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Year: 2001 PMID： 11741476 DOI： 10.1021/jm0102607
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446