| Literature DB >> 11741469 |
G Campiani1, E Morelli, V Nacci, C Fattorusso, A Ramunno, E Novellino, J Greenwood, T Liljefors, R Griffiths, C Sinclair, H Reavy, A S Kristensen, D S Pickering, A Schousboe, A Cagnotto, E Fumagalli, T Mennini.
Abstract
(S)-CPW399 (2b) is a novel, potent, and subtype-selective AMPA receptor full agonist that, unlike (S)-willardiine and related compounds, in mouse cerebellar granule cells, stimulated an increase in [Ca(2+)](i), and induced neuronal cell death in a time- and concentration-dependent manner. Compound 2b appears to be a weakly desensitizing, full agonist at AMPA receptors and therefore represents a new pharmacological tool to investigate the role of AMPA receptors in excitotoxicity and their molecular mechanisms of desensitization.Entities:
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Year: 2001 PMID： 11741469 DOI： 10.1021/jm015552m
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446