| Literature DB >> 11741468 |
Y T Chang1, S M Wignall, G R Rosania, N S Gray, S R Hanson, A I Su, J Merlie, H S Moon, S B Sangankar, O Perez, R Heald, P G Schultz.
Abstract
Myoseverin, a trisubstituted purine, inhibits microtubule assembly in vitro, interferes with normal mitotic spindle assembly, and arrests the cell cycle in mitosis in U937 cells. We synthesized a variety of myoseverin derivatives and screened them for inhibition of spindle assembly in Xenopus egg extracts and for microtubule disassembly in vitro. Selected compounds were tested against 60 cancer cell lines at the National Cancer Institute as possible anticancer drug candidates.Entities:
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Year: 2001 PMID： 11741468 DOI： 10.1021/jm010451+
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446