Literature DB >> 11740592

Phosphatase inhibitors prevent HSP27 dephosphorylation, destruction of stress fibrils, and morphological changes in endothelial cells during ATP depletion.

S A Loktionova1, A E Kabakov.   

Abstract

Pretreatment with phosphatase inhibitors did not affect the decrease in ATP content in endothelial cells, but inhibited HSP27 dephosphorylation and redistribution, damages to actin cytoskeleton, and morphological changes in cells. Our results suggest that inhibition of stress-induced HSP27 dephosphorylation protects cells from ischemia-induced damages.

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Year:  2001        PMID： 11740592     DOI： 10.1023/a:1013199508296

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

Review 1.  The role of cytoskeleton in the regulation of vascular endothelial barrier function.

Authors:  Natalia V Bogatcheva; Alexander D Verin
Journal:  Microvasc Res       Date:  2008-06-28       Impact factor: 3.514

Review 2.  Heat shock protein 27: its potential role in vascular disease.

Authors:  Gordon Ferns; Sedigheh Shams; Shahida Shafi
Journal:  Int J Exp Pathol       Date:  2006-08       Impact factor: 1.925

3.  Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC.

Authors:  Jun Ma; Lynetta Phillips; Ying Wang; Tiane Dai; Janine LaPage; Rama Natarajan; Sharon G Adler
Journal:  BMC Complement Altern Med       Date:  2010-11-12       Impact factor: 3.659

Review 4.  HSP27: mechanisms of cellular protection against neuronal injury.

Authors:  R A Stetler; Y Gao; A P Signore; G Cao; J Chen
Journal:  Curr Mol Med       Date:  2009-09       Impact factor: 2.222

5.  Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome.

Authors:  Majid Ghayour-Mobarhan; Amirhossein Sahebkar; Seyyed Mohammad Reza Parizadeh; Mohsen Moohebati; Shima Tavallaie; Seyyed Mohammad Rezakazemi-Bajestani; Habib-Allah Esmaeili; Gordon Ferns
Journal:  Int J Exp Pathol       Date:  2008-06       Impact factor: 1.925
  5 in total

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