Literature DB >> 11739707

Calcineurin-dependent mitochondrial disturbances in calcium-induced apoptosis of human immunodeficiency virus gp160-expressing CD4+ cells.

Masafumi Sasaki1, Kozo Miyazaki, Yasuhiro Koga, Genki Kimura, Kikuo Nomoto, Hiroki Yoshida.   

Abstract

In CD4+ UE160 cells with inducible expression of gp160, mechanisms of apoptosis induced by human immunodeficiency virus (HIV) Env protein were analyzed. Induction of gp160 caused intracellular calcium increase followed by the release of cytochrome c from mitochondria, which was inhibited by calcineurin inhibitors. Association of BAD with Bcl-xL was observed, and a portion of BAD was dephosphorylated after induction of gp160. These data suggested that calcineurin plays a role in the HIV Env-induced apoptosis in a mitochondrion-dependent way.

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Year:  2002        PMID： 11739707      PMCID： PMC135701          DOI： 10.1128/jvi.76.1.416-420.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

Authors:  H G Wang; N Pathan; I M Ethell; S Krajewski; Y Yamaguchi; F Shibasaki; F McKeon; T Bobo; T F Franke; J C Reed
Journal:  Science       Date:  1999-04-09       Impact factor: 47.728

2.  Cytopathic effect determined by the amount of CD4 molecules in human cell lines expressing envelope glycoprotein of HIV.

Authors:  Y Koga; M Sasaki; H Yoshida; H Wigzell; G Kimura; K Nomoto
Journal:  J Immunol       Date:  1990-01-01       Impact factor: 5.422

3.  Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.

Authors:  Y Y Lu; Y Koga; K Tanaka; M Sasaki; G Kimura; K Nomoto
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

4.  Effect of amino acid substitutions on calmodulin binding and cytolytic properties of the LLP-1 peptide segment of human immunodeficiency virus type 1 transmembrane protein.

Authors:  S B Tencza; M A Miller; K Islam; T A Mietzner; R C Montelaro
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

5.  Apoptosis and apoptosis-associated perturbations of peripheral blood lymphocytes during HIV infection: comparison between AIDS patients and asymptomatic long-term non-progressors.

Authors:  S Moretti; S Marcellini; A Boschini; G Famularo; G Santini; E Alesse; S M Steinberg; M G Cifone; G Kroemer; C De Simone
Journal:  Clin Exp Immunol       Date:  2000-12       Impact factor: 4.330

6.  The difference in gp160 and gp120 of HIV type 1 in the induction of CD4 downregulation preceding single-cell killing.

Authors:  Y Koga; K Nakamura; M Sasaki; G Kimura; K Nomoto
Journal:  Virology       Date:  1994-05-15       Impact factor: 3.616

Review 7.  Multifactorial nature of human immunodeficiency virus disease: implications for therapy.

Authors:  A S Fauci
Journal:  Science       Date:  1993-11-12       Impact factor: 47.728

8.  Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins.

Authors:  S K Srinivas; R V Srinivas; G M Anantharamaiah; R W Compans; J P Segrest
Journal:  J Biol Chem       Date:  1993-10-25       Impact factor: 5.157

9.  Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo.

Authors:  M Castedo; A Macho; N Zamzami; T Hirsch; P Marchetti; J Uriel; G Kroemer
Journal:  Eur J Immunol       Date:  1995-12       Impact factor: 5.532

10.  Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers.

Authors:  A Macho; M Castedo; P Marchetti; J J Aguilar; D Decaudin; N Zamzami; P M Girard; J Uriel; G Kroemer
Journal:  Blood       Date:  1995-10-01       Impact factor: 22.113
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  3 in total

1.  Altered mitochondrial dynamics as a consequence of Venezuelan Equine encephalitis virus infection.

Authors:  Forrest Keck; Taryn Brooks-Faulconer; Tyler Lark; Pavitra Ravishankar; Charles Bailey; Carolina Salvador-Morales; Aarthi Narayanan
Journal:  Virulence       Date:  2017-01-25       Impact factor: 5.882

2.  Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.

Authors:  Maria Castedo; Thomas Roumier; Julià Blanco; Karine F Ferri; Jordi Barretina; Lionel A Tintignac; Karine Andreau; Jean-Luc Perfettini; Alessandra Amendola; Roberta Nardacci; Philip Leduc; Donald E Ingber; Sabine Druillennec; Bernard Roques; Serge A Leibovitch; Montserrat Vilella-Bach; Jie Chen; José A Este; Nazanine Modjtahedi; Mauro Piacentini; Guido Kroemer
Journal:  EMBO J       Date:  2002-08-01       Impact factor: 11.598

3.  Role of mitochondria in parvovirus pathology.

Authors:  Jonna Nykky; Matti Vuento; Leona Gilbert
Journal:  PLoS One       Date:  2014-01-21       Impact factor: 3.240
  3 in total

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