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Literature DB >> 11739065

Estrogen replacement therapy and antidepressant response to sertraline in older depressed women.

Abstract

The influence of the use of estrogen replacement therapy (ERT) on the antidepressant response to sertraline of 127 women over 60 years old was evaluated with data from two multicenter trials. At endpoint, sertraline-treated women taking ERT had significantly greater global improvement and quality of life than those not receiving ERT. Modest improvements were also observed in anxiety symptoms and cognitive functioning. The results provide preliminary evidence that ERT use (without progesterone) in older depressed women may augment the antidepressant response to sertraline in terms of quality of life and general improvement.

Entities: Chemical Disease Species

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Year: 2001 PMID： 11739065

Source DB: PubMed Journal: Am J Geriatr Psychiatry ISSN： 1064-7481 Impact factor: 4.105

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Cited

28 in total

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5. The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women.

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6. Depression or menopause? Presentation and management of major depressive disorder in perimenopausal and postmenopausal women.

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Estrogen replacement therapy and antidepressant response to sertraline in older depressed women.

1. Recognizing and Treating the Physical Symptoms of Depression in Primary Care.

2. An Evidence-Based Approach to Augmentation and Combination Strategies for: Treatment-Resistant Depression.

Review 3. Depression in peri- and postmenopausal women: prevalence, pathophysiology and pharmacological management.

Review 4. Hormone treatment of depression.

5. The influence of menopause status and postmenopausal use of hormone therapy on presentation of major depression in women.

6. Depression or menopause? Presentation and management of major depressive disorder in perimenopausal and postmenopausal women.

Review 7. Evaluation of the potential antidepressant effects of soybean isoflavones.

Review 8. Effect of reproductive hormones and selective estrogen receptor modulators on mood during menopause.

9. Interaction between estrogens and antidepressants in the forced swimming test in rats.

10. Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test.