Literature DB >> 11738621

Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues.

Rahul Jain1, Jatinder Singh, Jeffery H Perlman, Marvin C Gershengorn.   

Abstract

We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.

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Year:  2002        PMID： 11738621     DOI： 10.1016/s0968-0896(01)00265-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues.

Authors:  Vikramdeep Monga; Chhuttan L Meena; Satyendra Rajput; Chandrashekhar Pawar; Shyam S Sharma; Xinping Lu; Marvin C Gershengorn; Rahul Jain
Journal:  ChemMedChem       Date:  2011-02-07       Impact factor: 3.466

2.  Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice.

Authors:  Chhuttan L Meena; Shubdha Ingole; Satyendra Rajpoot; Avinash Thakur; Prajwal P Nandeker; Abhay T Sangamwar; Shyam S Sharma; Rahul Jain
Journal:  RSC Adv       Date:  2015-06-23       Impact factor: 3.361

3.  Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{N-[(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-l-alanyl}-(2R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate).

Authors:  Naotake Kobayashi; Norihito Sato; Yuko Fujimura; Tsuyoshi Kihara; Katsuji Sugita; Kouji Takahashi; Katsumi Koike; Tamio Sugawara; Yukio Tada; Hiroshi Nakai; Takayoshi Yoshikawa
Journal:  ACS Omega       Date:  2018-10-19
  3 in total

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