| Literature DB >> 11738583 |
Wenqing Yao1, Michael Chao, Zelda R Wasserman, Rui Qin Liu, Maryanne B Covington, Robert Newton, David Christ, Ruth R Wexler, Carl P Decicco.
Abstract
A series of cis-1(S)2(R)-amino-2-indanol based compounds with a biphenylmethyl group at the P1' position was found to be potent aggrecanase inhibitors. Both compounds 2j and 2n possessed very high aggrecanase affinity (IC(50)=1.5nM), and showed excellent selectivity over MMP-1 and MMP-9, with moderate selectivity against MMP-2.Entities:
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Year: 2002 PMID： 11738583 DOI： 10.1016/s0960-894x(01)00704-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823