| Literature DB >> 11738575 |
Nobutoshi Murakami1, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi.
Abstract
In an explorative study for new anti-malarial substances using the methyl esters (1 and 2) of peroxyplakoric acids A(3) and B(3) as scaffolds, 6-carbomethoxymethyl-3-methoxy-3-pentyl-1,2-dioxane, which has been readily synthesized from 6-keto-alpha,beta-unsaturated ester, was found to exhibit potent anti-malarial activity with high selective toxicity.Entities:
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Year: 2002 PMID： 11738575 DOI： 10.1016/s0960-894x(01)00673-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823