B N Cuffin1, D L Schomer, J R Ives, H Blume. 1. Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue GZ-522, Boston, MA 00215, USA. bcuffin@caregroup.harvard.edu
Abstract
OBJECTIVES: To determine the accuracy with which electrical sources in the human brain can be located using realistically shaped boundary element models of the head and to compare this accuracy with that using spherical head models. METHODS: In a previous study, electroencephalographs (EEGs) produced by sources at known locations in the brains of human subjects were recorded. The sources were created by injecting current into implanted depth electrodes. The locations of the implanted depth and scalp EEG electrodes and head shape were determined from computerized tomography images. The EEGs were used to calculate source locations in spherical head models and localization accuracy was determined by comparing the calculated and actual locations. In this study, these same EEGs are used to determine localization accuracy in realistically shaped head models. RESULTS: An average localization error of 10.5 (SD=5.4) mm was obtained in the realistically shaped models for all 176 sources in 13 subjects. This compares with 10.6 (5.5) mm in the spherical models. The average localization error for 105 sources at superior locations in the brain is 9.1 (4.2) mm. The average error for 71 inferior location sources is 12.4 (6.4) mm. The corresponding values for the spherical models are 9.2 (4.4) and 12.8 (6.2) mm. CONCLUSIONS: The realistically shaped head boundary element models used in this study produced very nearly the same localization accuracy as spherical models.
OBJECTIVES: To determine the accuracy with which electrical sources in the human brain can be located using realistically shaped boundary element models of the head and to compare this accuracy with that using spherical head models. METHODS: In a previous study, electroencephalographs (EEGs) produced by sources at known locations in the brains of human subjects were recorded. The sources were created by injecting current into implanted depth electrodes. The locations of the implanted depth and scalp EEG electrodes and head shape were determined from computerized tomography images. The EEGs were used to calculate source locations in spherical head models and localization accuracy was determined by comparing the calculated and actual locations. In this study, these same EEGs are used to determine localization accuracy in realistically shaped head models. RESULTS: An average localization error of 10.5 (SD=5.4) mm was obtained in the realistically shaped models for all 176 sources in 13 subjects. This compares with 10.6 (5.5) mm in the spherical models. The average localization error for 105 sources at superior locations in the brain is 9.1 (4.2) mm. The average error for 71 inferior location sources is 12.4 (6.4) mm. The corresponding values for the spherical models are 9.2 (4.4) and 12.8 (6.2) mm. CONCLUSIONS: The realistically shaped head boundary element models used in this study produced very nearly the same localization accuracy as spherical models.
Authors: Gabriela Scheler; Michael J M Fischer; Alexandra Genow; Cornelia Hummel; Stefan Rampp; Andrea Paulini; Rüdiger Hopfengärtner; Martin Kaltenhäuser; Hermann Stefan Journal: Hum Brain Mapp Date: 2007-04 Impact factor: 5.038
Authors: Ming-Xiong Huang; Roland R Lee; Kathleen M Gaa; Tao Song; Deborah L Harrington; Cathy Loh; Rebecca J Theilmann; J Christopher Edgar; Gregory A Miller; Jose M Canive; Eric Granholm Journal: Brain Topogr Date: 2009-11-27 Impact factor: 3.020