Literature DB >> 11738175

Protein-protein interfaces: mimics and inhibitors.

A G Cochran1.   

Abstract

Many biological processes are mediated by specific molecular recognition between proteins. However, the thermodynamic and structural 'rules' for such recognition are incompletely understood, as is the potential for inhibition by small molecules. Recent progress has included the discovery of small-molecule inhibitors for several targets important in cancer.

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Year:  2001        PMID： 11738175     DOI： 10.1016/s1367-5931(01)00262-9

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  19 in total

1.  Binding of small molecules to an adaptive protein-protein interface.

Authors:  Michelle R Arkin; Mike Randal; Warren L DeLano; Jennifer Hyde; Tinh N Luong; Johan D Oslob; Darren R Raphael; Lisa Taylor; Jun Wang; Robert S McDowell; James A Wells; Andrew C Braisted
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-11       Impact factor: 11.205

2.  Short constrained peptides that inhibit HIV-1 entry.

Authors:  Samuel K Sia; Peter A Carr; Andrea G Cochran; Vladimir N Malashkevich; Peter S Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-04       Impact factor: 11.205

3.  Molecular recognition of protein surfaces: high affinity ligands for the CBP KIX domain.

Authors:  Stacey E Rutledge; Heather M Volkman; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2003-11-26       Impact factor: 15.419

Review 4.  Protein recognition using synthetic surface-targeted agents.

Authors:  Rishi Jain; Justin T Ernst; Olaf Kutzki; Hyung Soon Park; Andrew D Hamilton
Journal:  Mol Divers       Date:  2004       Impact factor: 2.943

5.  Development of small molecules designed to modulate protein-protein interactions.

Authors:  Ye Che; Bernard R Brooks; Garland R Marshall
Journal:  J Comput Aided Mol Des       Date:  2006-04-19       Impact factor: 3.686

6.  The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

Authors:  Mark F van Delft; Andrew H Wei; Kylie D Mason; Cassandra J Vandenberg; Lin Chen; Peter E Czabotar; Simon N Willis; Clare L Scott; Catherine L Day; Suzanne Cory; Jerry M Adams; Andrew W Roberts; David C S Huang
Journal:  Cancer Cell       Date:  2006-11       Impact factor: 31.743

7.  Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).

Authors:  Mengqi Zhong; Andrew Lynch; Samantha N Muellers; Stefan Jehle; Lingqi Luo; David R Hall; Reina Iwase; James P Carolan; Megan Egbert; Amanda Wakefield; Kristina Streu; Christine M Harvey; Paula C Ortet; Dima Kozakov; Sandor Vajda; Karen N Allen; Adrian Whitty
Journal:  Biochemistry       Date:  2020-01-02       Impact factor: 3.162

8.  Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions.

Authors:  Adriana Isvoran; Anne Badel; Constantin T Craescu; Simona Miron; Maria A Miteva
Journal:  BMC Struct Biol       Date:  2011-05-12

9.  Small Molecule Mimetics of α-Helical Domain of IRAK2 Attenuate the Proinflammatory Effects of IL-33 in Asthma-like Mouse Models.

Authors:  Jinghong Li; Kunio Saruta; Justin P Dumouchel; Jenna M Magat; Joanna L Thomas; Dariush Ajami; Mitra Rebek; Julius Rebek; Timothy D Bigby
Journal:  J Immunol       Date:  2018-05-04       Impact factor: 5.422

Review 10.  Computational and experimental approaches to chart the Escherichia coli cell-envelope-associated proteome and interactome.

Authors:  Juan Javier Díaz-Mejía; Mohan Babu; Andrew Emili
Journal:  FEMS Microbiol Rev       Date:  2008-11-27       Impact factor: 16.408
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