Literature DB >> 1173751

[Embryotoxicity and teratogenicity of derivatives of 1,3-indandion (author's transl)].

F Köhler, K Fickentscher, U Halfmann, H Koch.   

Abstract

The embryotoxicity and teratogenicity of 1,3-indandion and of 3 of its derivatives were proved. Pregnant SWS mice were given single i.p. injections on day 9 of gestation. A mixture of physiologic saline and TWEEN20 (3:1) was used as a solvent. The results refute the hypothesis of the action of thalidomide as an acylating agent responsible for the embryotoxic and teratogenic effect. The results favor instead the hypothesis of an intercalation of the flat purine-like molecule moieties of thalidomide and some of its analogues between base pairs of the DNA double helix.

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Year:  1975        PMID： 1173751     DOI： 10.1007/bf00311272

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  10 in total

1.  RIBONUCLEIC ACID POLYMERASE OF AZOTOBACTER VINELANDII. III. EFFECT OF POLYAMINES.

Authors:  J S KRAKOW
Journal:  Biochim Biophys Acta       Date:  1963-08-20

2.  [Teratological study on the thalidomide-like compounds K-2004 and K-2604 in the mouse and rat].

Authors:  F Köhler; H Koch
Journal:  Arzneimittelforschung       Date:  1974-10

3.  The hydrolysis of polyimides.

Authors:  P D Hoagland; S W Fox
Journal:  Experientia       Date:  1973-08-15

4.  Chemical structure and teratogenic properties. IV. An outline of a chemical hypothesis for the teratogenic action of thalidomide.

Authors:  N A Jönsson
Journal:  Acta Pharm Suec       Date:  1972-12

5.  [Teratological determination of some thalidomide metabolites].

Authors:  F Köhler; W Meise; H Ockenfels
Journal:  Experientia       Date:  1971-10-15

6.  Thalidomide. A study of biochemical teratology.

Authors:  R T Williams
Journal:  Arch Environ Health       Date:  1968-04

7.  [Teratogenic effect of N-phthalyl-DL-glutamic acid following intraperitoneal application in mice].

Authors:  F Köhler; H Ockenfels
Journal:  Experientia       Date:  1970-10-15

8.  [Experimental studies with cyclic imides. V. Cleavage of the phthalimide ring in thalidomide by amines].

Authors:  E Brode
Journal:  Arzneimittelforschung       Date:  1968-10

9.  Thalidomide as a possible biological acylating agent.

Authors:  S Fabro; R L Smith; R T Williams
Journal:  Nature       Date:  1965-12-18       Impact factor: 49.962

10.  Polyamines and nucleic acids during development of the chick embryo.

Authors:  C M Caldarera; B Barbiroli; G Moruzzi
Journal:  Biochem J       Date:  1965-10       Impact factor: 3.857
  10 in total
  3 in total

1.  Teratogenicity and embryotoxicity of some maleinimides.

Authors:  K Fickentscher; F Köhler
Journal:  Arch Toxicol       Date:  1976-12-23       Impact factor: 5.153

2.  Metabolic and toxic behavior of phthalimide derivates. I. Fate of imidan in the fetus.

Authors:  H Ackermann; H Seidler; Y S Kagan; V M Voronina
Journal:  Arch Toxicol       Date:  1976-10-28       Impact factor: 5.153

3.  Metabolic and toxic behaviours of phthalimide derivatives in albino rat II. Placental passage of chloromethyl phthalimide, oxymethyl phthalimide and phthalimide--their fetal metabolism.

Authors:  H Ackermann; H Faust; Y S Kagan; V H Voronina
Journal:  Arch Toxicol       Date:  1978-08-09       Impact factor: 5.153
  3 in total

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