PURPOSE: To evaluate any possible advantages of high-concentration gadolinium chelates in the human brain thin-slice MR. MATERIAL AND METHODS: Thirty-six patients were allocated into six groups. Three groups had perfusion imaging performed using 7-mm-thick slices and the other three groups had 4-mm-thick slices. One group who had 7-mm slices and one group of 4-mm slices had 0.5 M gadolinium (20 ml) whilst other groups received the high-concentration gadolinium (1.0 M: 10 ml and 20 ml). The time-intensity curves were analysed for maximum signal reduction and signal-to-noise measurements. RESULTS: Twenty ml of the 1.0-M agent produced significantly increased maximum signal change and improvement in signal-to-noise when compared to 20 ml of 0.5 M. There was no significant difference between the maximum signal change when 20 ml of 0.5 M and 10 ml of 1.0 M agents were compared. There was no significant difference between the maximum signal changes when 7-mm and 4-mm slice thickness using the same dosing regimens. CONCLUSION: Four-mm slice thickness perfusion imaging can be performed with high-concentration gadolinium in the human brain and we discuss the advantages of this.
PURPOSE: To evaluate any possible advantages of high-concentration gadolinium chelates in the human brain thin-slice MR. MATERIAL AND METHODS: Thirty-six patients were allocated into six groups. Three groups had perfusion imaging performed using 7-mm-thick slices and the other three groups had 4-mm-thick slices. One group who had 7-mm slices and one group of 4-mm slices had 0.5 M gadolinium (20 ml) whilst other groups received the high-concentration gadolinium (1.0 M: 10 ml and 20 ml). The time-intensity curves were analysed for maximum signal reduction and signal-to-noise measurements. RESULTS: Twenty ml of the 1.0-M agent produced significantly increased maximum signal change and improvement in signal-to-noise when compared to 20 ml of 0.5 M. There was no significant difference between the maximum signal change when 20 ml of 0.5 M and 10 ml of 1.0 M agents were compared. There was no significant difference between the maximum signal changes when 7-mm and 4-mm slice thickness using the same dosing regimens. CONCLUSION: Four-mm slice thickness perfusion imaging can be performed with high-concentration gadolinium in the human brain and we discuss the advantages of this.
Authors: Iain D Wilkinson; Paul D Griffiths; Nigel Hoggard; Trevor J Cleveland; Peter A Gaines; Sumaira Macdonald; Fiona McKevitt; Graham S Venables Journal: AJNR Am J Neuroradiol Date: 2003-09 Impact factor: 3.825
Authors: Csanad G Varallyay; Eric Nesbit; Andrea Horvath; Peter Varallyay; Rongwei Fu; Seymur Gahramanov; Leslie L Muldoon; Xin Li; William D Rooney; Edward A Neuwelt Journal: J Magn Reson Imaging Date: 2018-01-04 Impact factor: 4.813