Literature DB >> 11735619

Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging.

D A Le1, S A Lipton.   

Abstract

The N-methyl-D-aspartate (NMDA) receptor complex is a subtype of glutamate receptor and its dysfunction is involved in many neurological disorders associated with aging, including chronic pain, depression, stroke and Parkinson's disease. Multiple clinical trials using NMDA receptor antagonists have been aborted mainly due to the severe psychomimetic adverse effects of these drugs that occur before concentrations can reach an adequate level in the brain. In this review, we present the evidence that clinically safer NMDA antagonists such as memantine and nitroglycerin, and the combination drug nitro-memantine, are promising as drugs in treating neurodegenerative diseases.

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Year:  2001        PMID： 11735619     DOI： 10.2165/00002512-200118100-00001

Source DB:  PubMed          Journal:  Drugs Aging        ISSN： 1170-229X            Impact factor:   4.271


  66 in total

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Review 2.  The role of excitotoxicity in neurodegenerative disease: implications for therapy.

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Authors:  A J Hunter; K B Mackay; D C Rogers
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4.  Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.

Authors:  T Minami; E Okuda-Ashitaka; H Mori; K Sakimura; M Watanabe; M Mishina; S Ito
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

5.  Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism.

Authors:  H S Chen; S A Lipton
Journal:  J Physiol       Date:  1997-02-15       Impact factor: 5.182

6.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Authors:  J S Beckman; T W Beckman; J Chen; P A Marshall; B A Freeman
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7.  Memantine prevents HIV coat protein-induced neuronal injury in vitro.

Authors:  S A Lipton
Journal:  Neurology       Date:  1992-07       Impact factor: 9.910

8.  Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.

Authors:  Y Choi; H V Chen; S A Lipton
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

9.  Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon.

Authors:  H Sawada; S Shimohama; Y Tamura; T Kawamura; A Akaike; J Kimura
Journal:  J Neurosci Res       Date:  1996-01-01       Impact factor: 4.164

10.  Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.

Authors:  G L Collingridge; S J Kehl; H McLennan
Journal:  J Physiol       Date:  1983-01       Impact factor: 5.182
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  15 in total

1.  Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release.

Authors:  C M Norris; E M Blalock; O Thibault; L D Brewer; G V Clodfelter; N M Porter; P W Landfield
Journal:  J Neurophysiol       Date:  2006-08-16       Impact factor: 2.714

Review 2.  Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults.

Authors:  Stuart A Lipton
Journal:  NeuroRx       Date:  2004-01

3.  Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain.

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Journal:  Exp Neurol       Date:  2010-03-29       Impact factor: 5.330

4.  Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

Authors:  Mark E Layton; Michael J Kelly; Kevin J Rodzinak; Philip E Sanderson; Steven D Young; Rodney A Bednar; Anthony G Dilella; Terrence P McDonald; Hao Wang; Scott D Mosser; John F Fay; Michael E Cunningham; Duane R Reiss; Christine Fandozzi; Nicole Trainor; Annie Liang; Edward V Lis; Guy R Seabrook; Mark O Urban; James Yergey; Kenneth S Koblan
Journal:  ACS Chem Neurosci       Date:  2011-04-15       Impact factor: 4.418

Review 5.  Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability.

Authors:  Roberto Rodrigues; Robert B Petersen; George Perry
Journal:  Cell Mol Neurobiol       Date:  2014-06-14       Impact factor: 5.046

Review 6.  Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.

Authors:  Natik Piri; Jacky M K Kwong; Lei Gu; Joseph Caprioli
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7.  Celastrol supports survival of retinal ganglion cells injured by optic nerve crush.

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Review 8.  Spinocerebellar degenerations: an update.

Authors:  Susan L Perlman
Journal:  Curr Neurol Neurosci Rep       Date:  2002-07       Impact factor: 5.081

9.  Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor.

Authors:  X-K Wee; K-S Ng; H-W Leung; Y-P Cheong; K-H Kong; F-M Ng; W Soh; Y Lam; C-M Low
Journal:  Br J Pharmacol       Date:  2010-01-15       Impact factor: 8.739

10.  Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions.

Authors:  Stanislav Micuda; Lucie Mundlova; Eva Anzenbacherova; Pavel Anzenbacher; Jaroslav Chladek; Leos Fuksa; Jirina Martinkova
Journal:  Eur J Clin Pharmacol       Date:  2004-09-16       Impact factor: 2.953
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