Literature DB >> 11735525

Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy.

A Boeijen1, J van Ameijde, R M Liskamp.   

Abstract

A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

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Year:  2001        PMID: 11735525     DOI: 10.1021/jo010656q

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.

Authors:  Pijus K Mandal; Zhiyong Ren; Xiaomin Chen; Chiyi Xiong; John S McMurray
Journal:  J Med Chem       Date:  2009-10-08       Impact factor: 7.446

2.  Biosynthesis of fragin is controlled by a novel quorum sensing signal.

Authors:  Christian Jenul; Simon Sieber; Christophe Daeppen; Anugraha Mathew; Martina Lardi; Gabriella Pessi; Dominic Hoepfner; Markus Neuburger; Anthony Linden; Karl Gademann; Leo Eberl
Journal:  Nat Commun       Date:  2018-03-30       Impact factor: 14.919

  2 in total

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