| Literature DB >> 11735220 |
L C McCarthy1, D A Hosford, J H Riley, M I Bird, N J White, D R Hewett, S J Peroutka, L R Griffiths, P R Boyd, R A Lea, S M Bhatti, L K Hosking, C M Hood, K W Jones, A R Handley, R Rallan, K F Lewis, A J Yeo, P M Williams, R C Priest, P Khan, C Donnelly, S M Lumsden, J O'Sullivan, C G See, D H Smart, S Shaw-Hawkins, J Patel, T C Langrish, W Feniuk, R G Knowles, M Thomas, V Libri, D S Montgomery, P K Manasco, C F Xu, C Dykes, P P Humphrey, A D Roses, I J Purvis.
Abstract
We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.Entities:
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Year: 2001 PMID： 11735220 DOI： 10.1006/geno.2001.6647
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736