Literature DB >> 11735173

The significance of human telomerase reverse transcriptase (hTERT) in cancer.

K L Kirkpatrick1, K Mokbel.   

Abstract

Since the discovery of the enzyme telomerase in humans, it has become apparent that it is the most general of tumour markers known, and enormously significant in its potential for diagnostic, prognostic and therapeutic applications. Extensive work has identified three core components of the enzyme, of which the catalytic subunit hTERT (human telomerase reverse transcriptase) appears to be the most important. The aim of this article is to review the current evidence for the function and activity of hTERT in malignant conditions, and to discuss the future possibilities in terms of cancer diagnosis and treatment. Copyright Harcourt Publishers Limited.

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Year:  2001        PMID： 11735173     DOI： 10.1053/ejso.2001.1151

Source DB:  PubMed          Journal:  Eur J Surg Oncol        ISSN： 0748-7983            Impact factor:   4.424


  19 in total

1.  Effects of cadmium on telomerase activity, expressions of TERT, c-myc and P53, and apoptosis of rat hepatocytes.

Authors:  Wentao Dai; Huajie Chen; Rian Yu; Lingfei He; Bing Chen; Xuemin Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2010-12-22

2.  Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines.

Authors:  Joseph George; Naren L Banik; Swapan K Ray
Journal:  Int J Biochem Cell Biol       Date:  2010-04-13       Impact factor: 5.085

3.  Sequential hTERT knockdown and apigenin treatment inhibited invasion and proliferation and induced apoptosis in human malignant neuroblastoma SK-N-DZ and SK-N-BE2 cells.

Authors:  Mrinmay Chakrabarti; Naren L Banik; Swapan K Ray
Journal:  J Mol Neurosci       Date:  2013-02-17       Impact factor: 3.444

4.  Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.

Authors:  Ivo S Muskens; Helen M Hansen; Ivan V Smirnov; Annette M Molinaro; Melissa L Bondy; Joellen M Schildkraut; Margaret Wrensch; Joseph L Wiemels; Elizabeth B Claus
Journal:  J Neurooncol       Date:  2019-02-22       Impact factor: 4.130

5.  Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas.

Authors:  Lukasz-Filip Grochola; Thomas Greither; Helge W Taubert; Peter Möller; Uwe Knippschild; Andrej Udelnow; Doris Henne-Bruns; Peter Würl
Journal:  Neoplasia       Date:  2008-09       Impact factor: 5.715

6.  hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer.

Authors:  A E Elkak; G Meligonis; M Salhab; B Mitchell; J R S Blake; R F Newbold; K Mokbel
Journal:  J Carcinog       Date:  2005-10-04

7.  The expression of hTR and hTERT in human breast cancer: correlation with clinico-pathological parameters.

Authors:  Saied Hosseini-Asl; Morteza Atri; Mohammad H Modarressi; Mohamed Salhab; Kefah Mokbel; Parvin Mehdipour
Journal:  Int Semin Surg Oncol       Date:  2006-08-22

8.  Co-existence of BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma is associated with tumor aggressiveness, but not with lymph node metastasis.

Authors:  Haoyu Ren; Yifan Shen; Daixing Hu; Wei He; Jing Zhou; Yijia Cao; Yu Mao; Yi Dou; Wei Xiong; Qi Xiao; Yuhong Zhang; Xinliang Su
Journal:  Cancer Manag Res       Date:  2018-05-03       Impact factor: 3.989

9.  There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer.

Authors:  Katharine L Kirkpatrick; Robert F Newbold; Kefah Mokbel
Journal:  Int Semin Surg Oncol       Date:  2004-05-06

10.  The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression.

Authors:  Katharine L Kirkpatrick; Robert F Newbold; Kefah Mokbel
Journal:  J Carcinog       Date:  2004-01-22
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