Y Totan1, O Cekiç, M Borazan, E Uz, S Sögüt, O Akyol. 1. Department of Ophthalmology, Turgut Ozal Medical Centre, Inönü University School of Medicine, 44300 Malatya, Turkey. ytotan@usa.net
Abstract
AIMS: To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS: Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS: Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION: The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.
AIMS: To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). METHODS: Plasma nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. RESULTS: Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). CONCLUSION: The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.
Authors: Maria Fernanda Suarez; Maria Carmen Piqueras; Leandro Correa; Evangelina Esposito; Maria Fernanda Barros; Sanjoy K Bhattacharya; Julio A Urrets-Zavalia; Horacio M Serra Journal: J Cell Biochem Date: 2017-05-23 Impact factor: 4.429