| Literature DB >> 11731802 |
Susan L Andersen1, Andreas Arvanitogiannis, Andrea M Pliakas, Celeste LeBlanc, William A Carlezon.
Abstract
Evidence in laboratory animals indicates that exposure to stimulants produces sensitization to their rewarding effects, a process that in humans would be expected to increase the risk of substance abuse. However, therapeutic administration of stimulants such as methylphenidate (MPH) in children with attention deficit hyperactivity disorder reportedly reduces the risk of substance abuse. Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine.Entities:
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Year: 2002 PMID： 11731802 DOI： 10.1038/nn777
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884