Literature DB >> 1173020

The hypercalcaemic syndrome in rats bearing the Walker carcinosarcoma 256.

H Minne, F Raue, S Bellwinkel, R Ziegler.   

Abstract

The strain of Walker carcinosarcoma 256 described induces hypercalcaemia, hyperphosphataemia and hyperuraemia in tumour bearing rats. Changes in calcium and phosphorus excretion are observed as well as accompanying calcification of soft tissue organs and loss of bone calcium. These changes in calcium metabolism disappear after removal of the tumour, so that long-range action of the tumour can be stated. The results are discussed in comparison with three other animal models of tumour dependent hypercalcaemia.

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Year:  1975        PMID： 1173020     DOI： 10.1530/acta.0.0780613

Source DB:  PubMed          Journal:  Acta Endocrinol (Copenh)        ISSN： 0001-5598


  15 in total

1.  Dynamics of osteoclasia in rats with Walker tumor.

Authors:  A Schäfer; F Raue; H Minne; R Ziegler
Journal:  Calcif Tissue Res       Date:  1977-05

2.  The Walker 256/B carcinosarcoma in thyroparathyroidectomized rats: a model to evaluate inhibitors of bone resorption.

Authors:  R Rizzoli; H Fleisch
Journal:  Calcif Tissue Int       Date:  1987-10       Impact factor: 4.333

3.  In vitro effects of bone- and platelet-derived transforming growth factor-beta on the growth of Walker 256 carcinosarcoma cells.

Authors:  W Millar-Book; F W Orr; G Singh
Journal:  Clin Exp Metastasis       Date:  1990 Nov-Dec       Impact factor: 5.150

4.  Determination of trace elements in peripheral lymphocytes from tumor-bearing rats.

Authors:  J Schuhmacher; J Mattern; M Volm; K Wayss
Journal:  Experientia       Date:  1979-01-15

5.  Partial characterization of a bone-derived chemotactic factor for tumor cells.

Authors:  F W Orr; J Varani; M D Gondek; P A Ward; G R Mundy
Journal:  Am J Pathol       Date:  1980-04       Impact factor: 4.307

Review 6.  Hypercalcaemia of malignancy.

Authors:  P J Kelly; J A Eisman
Journal:  Cancer Metastasis Rev       Date:  1989-06       Impact factor: 9.264

7.  Different effects of hypercalcemic state induced by Walker tumor (HWCS 256) and 1,25 (OH)D3 intoxication on rat thyroid C cells. An ultrastructural, immunocytochemical, and biochemical study.

Authors:  E Rix; F Raue; I Deutschle; R Ziegler
Journal:  Histochemistry       Date:  1984

8.  A quantitative model for spontaneous bone metastasis: evidence for a mitogenic effect of bone on Walker 256 cancer cells.

Authors:  P J Kostenuik; G Singh; K L Suyama; F W Orr
Journal:  Clin Exp Metastasis       Date:  1992-11       Impact factor: 5.150

9.  Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.

Authors:  S B Rodan; K L Insogna; A M Vignery; A F Stewart; A E Broadus; S M D'Souza; D R Bertolini; G R Mundy; G A Rodan
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808

10.  A model for malignancy-associated humoral hypercalcemia.

Authors:  E C Abramson; L J Kukla; D H Shevrin; T E Lad; W P McGuire; S C Kukreja
Journal:  Calcif Tissue Int       Date:  1984-09       Impact factor: 4.333
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