Literature DB >> 11727994

Secondary DNA structure analysis of the coding strand switch regions of five Leishmania major Friedlin chromosomes.

V Tosato1, L Ciarloni, A C Ivens, M A Rajandream, B G Barrell, C V Bruschi.   

Abstract

As part of the EULEISH international genome project, a region of 74,674 nucleotides from chromosome 21 of Leishmania major Friedlin was subcloned and sequenced; and 31 new coding sequences were predicted. Of particular interest was a unique coding strand switching region covering 1.6 kb of DNA; and this was subjected to further investigation. Bioinformatic analysis of this region revealed an unusually high AT composition, a lack of putative hairpins and a strong curvature of the DNA in agreement with the structural characteristics of similar regions of other Leishmania chromosomes. These observations and a comparison with the secondary DNA structure of four other Leishmania chromosomes and chromosomes of different organisms could suggest a functional role of this region in transcription and mitotic division.

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Year:  2001        PMID： 11727994     DOI： 10.1007/s002940100246

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  9 in total

1.  Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene.

Authors:  E A Worthey; Santiago Martinez-Calvillo; Achim Schnaufer; Gautam Aggarwal; Jason Cawthra; Gholam Fazelinia; Chris Fong; Guoliang Fu; Melissa Hassebrock; Greg Hixson; Alasdair C Ivens; Patti Kiser; Felicia Marsolini; Erika Rickel; Erica Rickell; Reza Salavati; Ellen Sisk; Susan M Sunkin; Kenneth D Stuart; Peter J Myler
Journal:  Nucleic Acids Res       Date:  2003-07-15       Impact factor: 16.971

2.  The switch region on Leishmania major chromosome 1 is not required for mitotic stability or gene expression, but appears to be essential.

Authors:  Pascal Dubessay; Christophe Ravel; Patrick Bastien; Lucien Crobu; Jean-Pierre Dedet; Michel Pagès; Christine Blaineau
Journal:  Nucleic Acids Res       Date:  2002-09-01       Impact factor: 16.971

3.  The genome of the kinetoplastid parasite, Leishmania major.

Authors:  Alasdair C Ivens; Christopher S Peacock; Elizabeth A Worthey; Lee Murphy; Gautam Aggarwal; Matthew Berriman; Ellen Sisk; Marie-Adele Rajandream; Ellen Adlem; Rita Aert; Atashi Anupama; Zina Apostolou; Philip Attipoe; Nathalie Bason; Christopher Bauser; Alfred Beck; Stephen M Beverley; Gabriella Bianchettin; Katja Borzym; Gordana Bothe; Carlo V Bruschi; Matt Collins; Eithon Cadag; Laura Ciarloni; Christine Clayton; Richard M R Coulson; Ann Cronin; Angela K Cruz; Robert M Davies; Javier De Gaudenzi; Deborah E Dobson; Andreas Duesterhoeft; Gholam Fazelina; Nigel Fosker; Alberto Carlos Frasch; Audrey Fraser; Monika Fuchs; Claudia Gabel; Arlette Goble; André Goffeau; David Harris; Christiane Hertz-Fowler; Helmut Hilbert; David Horn; Yiting Huang; Sven Klages; Andrew Knights; Michael Kube; Natasha Larke; Lyudmila Litvin; Angela Lord; Tin Louie; Marco Marra; David Masuy; Keith Matthews; Shulamit Michaeli; Jeremy C Mottram; Silke Müller-Auer; Heather Munden; Siri Nelson; Halina Norbertczak; Karen Oliver; Susan O'neil; Martin Pentony; Thomas M Pohl; Claire Price; Bénédicte Purnelle; Michael A Quail; Ester Rabbinowitsch; Richard Reinhardt; Michael Rieger; Joel Rinta; Johan Robben; Laura Robertson; Jeronimo C Ruiz; Simon Rutter; David Saunders; Melanie Schäfer; Jacquie Schein; David C Schwartz; Kathy Seeger; Amber Seyler; Sarah Sharp; Heesun Shin; Dhileep Sivam; Rob Squares; Steve Squares; Valentina Tosato; Christy Vogt; Guido Volckaert; Rolf Wambutt; Tim Warren; Holger Wedler; John Woodward; Shiguo Zhou; Wolfgang Zimmermann; Deborah F Smith; Jenefer M Blackwell; Kenneth D Stuart; Bart Barrell; Peter J Myler
Journal:  Science       Date:  2005-07-15       Impact factor: 47.728

4.  Molecular and cellular characterization of an AT-hook protein from Leishmania.

Authors:  Ben L Kelly; Gyanendra Singh; Ashok Aiyar
Journal:  PLoS One       Date:  2011-06-23       Impact factor: 3.240

5.  Compared genomics of the strand switch region of Leishmania chromosome 1 reveal a novel genus-specific gene and conserved structural features and sequence motifs.

Authors:  Jacques Puechberty; Christine Blaineau; Sabrina Meghamla; Lucien Crobu; Michel Pagès; Patrick Bastien
Journal:  BMC Genomics       Date:  2007-02-24       Impact factor: 3.969

6.  Intrinsic DNA curvature in trypanosomes.

Authors:  Pablo Smircich; Najib M El-Sayed; Beatriz Garat
Journal:  BMC Res Notes       Date:  2017-11-09

7.  Histone acetylations mark origins of polycistronic transcription in Leishmania major.

Authors:  Sean Thomas; Amanda Green; Nancy R Sturm; David A Campbell; Peter J Myler
Journal:  BMC Genomics       Date:  2009-04-08       Impact factor: 3.969

8.  Organization and evolution of two SIDER retroposon subfamilies and their impact on the Leishmania genome.

Authors:  Martin Smith; Frédéric Bringaud; Barbara Papadopoulou
Journal:  BMC Genomics       Date:  2009-05-22       Impact factor: 3.969

9.  Genomic analysis of sequence-dependent DNA curvature in Leishmania.

Authors:  Pablo Smircich; Diego Forteza; Najib M El-Sayed; Beatriz Garat
Journal:  PLoS One       Date:  2013-04-30       Impact factor: 3.240
  9 in total

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