OBJECTIVE: To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. METHODS: Endothelial derived ET-1, t-PA, PAI-1, and platelet derived beta-TG, PDGF, TGF-beta were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. RESULTS: A significative increase of ET-1, t-PA, PAI-1, TGF-beta, and beta-TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and beta-TG levels were observed in patients with primary RP vs controls. CONCLUSIONS: These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.
OBJECTIVE: To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. METHODS: Endothelial derived ET-1, t-PA, PAI-1, and platelet derived beta-TG, PDGF, TGF-beta were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. RESULTS: A significative increase of ET-1, t-PA, PAI-1, TGF-beta, and beta-TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and beta-TG levels were observed in patients with primary RP vs controls. CONCLUSIONS: These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.
Authors: Serdar Soydinc; Ibrahim Halil Turkbeyler; Yavuz Pehlivan; Gulcimen Soylu; Mehmet Fatih Goktepe; Muhammed Bilici; Orhan Zengin; Bunyamin Kisacik; Ahmet Mesut Onat Journal: Inflammation Date: 2014-02 Impact factor: 4.092
Authors: Giuseppe A Ramirez; Stefano Franchini; Patrizia Rovere-Querini; Maria Grazia Sabbadini; Angelo A Manfredi; Norma Maugeri Journal: Front Immunol Date: 2012-06-18 Impact factor: 7.561
Authors: S Fessatou; P Nicolaidou; D Gourgiotis; H Georgouli; K Douros; M Moustaki; A Fretzayas Journal: BMC Pediatr Date: 2008-09-02 Impact factor: 2.125
Authors: Daniela Hirigoyen; Paula I Burgos; Veronica Mezzano; Josefina Duran; Magaly Barrientos; Claudia G Saez; Olga Panes; Diego Mezzano; Mirentxu Iruretagoyena Journal: Arthritis Res Ther Date: 2015-11-19 Impact factor: 5.156