Literature DB >> 11727309

Total synthesis of natural product DNA cross-linking agents.

R S Coleman1.   

Abstract

A variety of naturally occurring compounds interact with duplex DNA by the formation of covalent cross-links. This review describes recent progress on the total synthesis of four natural product families, including the mitomycins, the structurally and functionally related agent FR-900482, the bis-pyrrole isochrysohermidine and the azinomycins.

Entities:  

Mesh:

Substances:

Year:  2001        PMID: 11727309

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN: 1367-6733


  2 in total

Review 1.  Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.

Authors:  Phillip D Bass; Daniel A Gubler; Ted C Judd; Robert M Williams
Journal:  Chem Rev       Date:  2013-05-08       Impact factor: 60.622

2.  Development of a flexible strategy towards FR900482 and the mitomycins.

Authors:  Barry M Trost; Brendan M O'Boyle; Wildeliz Torres; Michael K Ameriks
Journal:  Chemistry       Date:  2011-05-26       Impact factor: 5.236

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.