Literature DB >> 11726284

Identification and characterization of CaMKP-N, nuclear calmodulin-dependent protein kinase phosphatase.

M Takeuchi1, A Ishida, I Kameshita, T Kitani, S Okuno, H Fujisawa.   

Abstract

Calmodulin-dependent protein kinase phosphatase (CaMKP) dephosphorylates and concomitantly deactivates multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs), such as CaMKI, CaMKII, and CaMKIV. In the present study, a nuclear CaMKP-related protein, CaMKP-N, was identified. This protein consisted of 757 amino acid residues with a calculated molecular weight of 84,176. Recombinant CaMKP-N dephosphorylated CaMKIV. The activity of CaMKP-N requires Mn(2+) ions and is stimulated by polycations. Transiently expressed CaMKP-N in COS-7 cells was localized in the nucleus. This finding together with previous reports regarding localization of CaMKs indicates that CaMKP-N dephosphorylates CaMKIV and nuclear CaMKII, whereas CaMKP dephosphorylates CaMKI and cytosolic CaMKII.

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Year:  2001        PMID： 11726284     DOI： 10.1093/oxfordjournals.jbchem.a003055

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  7 in total

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Authors:  Yu-Pu Jing; Wen Liu; Jin-Xing Wang; Xiao-Fan Zhao
Journal:  J Biol Chem       Date:  2015-02-10       Impact factor: 5.157

2.  Effects of manganese deficiency on the microstructure of proximal tibia and OPG/RANKL gene expression in chicks.

Authors:  Ran Liu; Cong Jin; Zhenyong Wang; Zhaojun Wang; Jian Wang; Lin Wang
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Review 3.  Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases.

Authors:  A Ishida; N Sueyoshi; Y Shigeri; I Kameshita
Journal:  Br J Pharmacol       Date:  2008-05-05       Impact factor: 8.739

4.  Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

Authors:  Jun-ichi Saito; Shinnosuke Toriumi; Kenjiro Awano; Hidenori Ichijo; Keiichi Sasaki; Takayasu Kobayashi; Shinri Tamura
Journal:  Biochem J       Date:  2007-08-01       Impact factor: 3.857

5.  An active C-terminally truncated form of Ca (2+) /calmodulin-dependent protein kinase phosphatase-N (CaMKP-N/PPM1E).

Authors:  Atsuhiko Ishida; Kumiko Tsumura; Megu Oue; Yasuhiro Takenaka; Yasushi Shigeri; Naoki Goshima; Yasuhiro Ishihara; Tetsuo Hirano; Hiromi Baba; Noriyuki Sueyoshi; Isamu Kameshita; Takeshi Yamazaki
Journal:  Biomed Res Int       Date:  2013-08-07       Impact factor: 3.411

6.  Gender-specific potential inhibitory role of Ca2+/calmodulin dependent protein kinase phosphatase (CaMKP) in pressure-overloaded mouse heart.

Authors:  Miresta Prévilon; Mylène Pezet; Laurent Vinet; Jean-Jacques Mercadier; Patricia Rouet-Benzineb
Journal:  PLoS One       Date:  2014-03-07       Impact factor: 3.240

7.  miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone.

Authors:  Jian-Bo Fan; Jian-Wei Ruan; Wei Liu; Lun-Qing Zhu; Xin-Hui Zhu; Hong Yi; Sheng-Yu Cui; Jian-Ning Zhao; Zhi-Ming Cui
Journal:  Oncotarget       Date:  2016-10-25
  7 in total

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