U Hobohm1. 1. F. Hoffmann-La Roche Ltd., Pharma Research, Basel, Switzerland. uwe.hobohm@roche.com
Abstract
CONTEXT: A relationship between feverish infection and concurrent remission from cancer has been known about for a very long time. However, a systematic investigation of the phenomenon has not yet been made. OBJECTIVE: To bring together the isolated observations about the coincidence of spontaneous remissions with feverish infections and William Coley's seminal work, as a basis for devising an immunological hypothesis about the putative anti-cancer effect of fever. CONCLUSION: Fever induction under medical guidance may be considered as part of a therapy regimen for cancers of mesodermal origin.
CONTEXT: A relationship between feverish infection and concurrent remission from cancer has been known about for a very long time. However, a systematic investigation of the phenomenon has not yet been made. OBJECTIVE: To bring together the isolated observations about the coincidence of spontaneous remissions with feverish infections and William Coley's seminal work, as a basis for devising an immunological hypothesis about the putative anti-cancer effect of fever. CONCLUSION:Fever induction under medical guidance may be considered as part of a therapy regimen for cancers of mesodermal origin.
Authors: David A Reardon; Gordon Freeman; Catherine Wu; E Antonio Chiocca; Kai W Wucherpfennig; Patrick Y Wen; Edward F Fritsch; William T Curry; John H Sampson; Glenn Dranoff Journal: Neuro Oncol Date: 2014-09-04 Impact factor: 12.300
Authors: Ulrich Geyer; Klas Diederich; Maria Kusserow; Andreas Laubersheimer; Klaus Kramer Journal: Evid Based Complement Alternat Med Date: 2013-05-22 Impact factor: 2.629