Literature DB >> 11725963

Gastric-mucous membrane protection activity of coptisine derivatives.

H Hirano1, E Osawa, Y Yamaoka, T Yokoi.   

Abstract

Coptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11725963     DOI： 10.1248/bpb.24.1277

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  5 in total

1.  Development of monoclonal antibody against isoquinoline alkaloid coptisine and its application for the screening of medicinal plants.

Authors:  Jun-Sik Kim; Hiroyuki Tanaka; Chun-Su Yuan; Yukihiro Shoyama
Journal:  Cytotechnology       Date:  2004-03       Impact factor: 2.058

2.  Banhasasim-Tang Treatment Reduces the Severity of Esophageal Mucosal Ulcer on Chronic Acid Reflux Esophagitis in Rats.

Authors:  Mi-Rae Shin; Bu-Il Seo; Chang Gue Son; Seong-Soo Roh; Hyo-Jin An
Journal:  Biomed Res Int       Date:  2017-03-02       Impact factor: 3.411

3.  Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process.

Authors:  Cailan Li; Ping Huang; Kambo Wong; Yifei Xu; Lihua Tan; Hanbin Chen; Qiang Lu; Chaodan Luo; Chunlai Tam; Lixiang Zhu; Ziren Su; Jianhui Xie
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

4.  Pharmacokinetics Studies of 12 Alkaloids in Rat Plasma after Oral Administration of Zuojin and Fan-Zuojin Formulas.

Authors:  Ping Qian; You-Bo Zhang; Yan-Fang Yang; Wei Xu; Xiu-Wei Yang
Journal:  Molecules       Date:  2017-01-30       Impact factor: 4.411

Review 5.  Gastric and duodenal antiulcer activity of alkaloids: a review.

Authors:  Heloina de Sousa Falcão; Jacqueline Alves Leite; José Maria Barbosa-Filho; Petrônio Filgueiras de Athayde-Filho; Maria Célia de Oliveira Chaves; Marcelo Dantas Moura; Anderson Luiz Ferreira; Ana Beatriz Albino de Almeida; Alba Regina Monteiro Souza-Brito; Margareth de Fátima Formiga Melo Diniz; Leônia Maria Batista
Journal:  Molecules       Date:  2008-12-17       Impact factor: 4.411
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.