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Literature DB >> 1172451

The gamma-aminobutyric acid system in rat cerebellum during cannabinoid-induced cataleptoid state.

Abstract

Repeated, but not single, intraperitoneal injections of delta1,6-tetrahydrocannabinol (delta1,6-THC) 20 mg/kg to rats administered daily for two weeks, produced increased gamma-aminobutyric acid (GABA) concentration and decreased glutamic acid decarboxylase (GAD) activity in the cerebellum, as well as enhancement of [3H]-GABA uptake by cerebellar crude synaptosomes. It seems that the motor impairment elicited by delta1,6-THC was not associated with the GABA system, but presumably might be related to changes in brain excitability.

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Year: 1975 PMID： 1172451 PMCID： PMC1666468 DOI： 10.1111/j.1476-5381.1975.tb07584.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

11 in total

Review 1. GAMMA-AMINOBUTYRIC ACID AND OTHER INHIBITORY SUBSTANCES.

Authors: K A ELLIOTT
Journal: Br Med Bull Date: 1965-01 Impact factor: 4.291

2. Some properties of L-glutamic decarboxylase in mouse brain.

Authors: E ROBERTS; D G SIMONSEN
Journal: Biochem Pharmacol Date: 1963-02 Impact factor: 5.858

3. In vivo effect of LSD, morphine, ethanol and delta9-tetrahydrocannabinol on mouse brain adenosine triphosphatase activity.

Authors: M L Jain; B M Curtis; E V Bakutis
Journal: Res Commun Chem Pathol Pharmacol Date: 1974-01

4. 9 -Tetrahydrocannabinol: effects of EEG and behavior of rhesus monkeys.

Authors: J L Martinez; S W Stadnicki; U H Schaeppi
Journal: Life Sci I Date: 1972-07-01

5. GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors.

Authors: L L Iversen; G A Johnston
Journal: J Neurochem Date: 1971-10 Impact factor: 5.372

The gamma-aminobutyric acid system in rat cerebellum during cannabinoid-induced cataleptoid state.

Review 1. GAMMA-AMINOBUTYRIC ACID AND OTHER INHIBITORY SUBSTANCES.

2. Some properties of L-glutamic decarboxylase in mouse brain.

3. In vivo effect of LSD, morphine, ethanol and delta9-tetrahydrocannabinol on mouse brain adenosine triphosphatase activity.

4. 9 -Tetrahydrocannabinol: effects of EEG and behavior of rhesus monkeys.

5. GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors.

6. The uptake of [3H]GABA by slices of rat cerebral cortex.

7. GABA as a repressor of L-glutamic acid decarboxylase (GAD) in developing chick embryo optic lobes.

8. The gamma-aminobutyric acid system in rabbit cerebellum.

9. Further studies on the binding of gamma-aminobutyric acid by brain.

10. Psychopharmacological activity of the active constituents of hashish and some related cannabinoids.

1. Olfactory Hallucinations without Clinical Motor Activity: A Comparison of Unirhinal with Birhinal Phantosmia.

2. Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex.