| Literature DB >> 11724309 |
K Inoue1, Y Kawahito, Y Tsubouchi, R Yamada, M Kohno, Y Hosokawa, D Katoh, D Bishop-Bailey, T Hla, H Sano.
Abstract
The peroxisome proliferator-activated receptor (PPAR)-gamma is a member of the steroid nuclear receptors. Recent studies have demonstrated that PPAR-gamma is expressed in several cancer cells. We examined the PPAR-gamma expression in both normal lung and major types of human lung cancer. The expression of PPAR-gamma mRNA was detected in 2 out of 3 normal lung tissues and its protein was detected in 3 out of 5 normal lung tissues. In contrast, a small cell carcinoma cell line and all other types of lung cancer tissues expressed PPAR-gamma mRNA and its protein. Immunoreactive PPAR-gamma is strongly expressed in cancer cells and moderately in mononuclear cells, endothelial cells and fibroblasts of lung cancer tissues. Our results suggest that PPAR-gamma may play an important role in the pathogenesis and/or progression of lung cancer, and may be a novel therapeutical target for therapy of lung cancer.Entities:
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Year: 2001 PMID： 11724309
Source DB: PubMed Journal: Anticancer Res ISSN： 0250-7005 Impact factor: 2.480