Literature DB >> 11724267

Characterization of RNA synthesis and translation of bovine viral diarrhea virus (BVDV).

Y Li1, J McNally.   

Abstract

Full length and replicon genomes of various strains of bovine viral diarrhea virus (BVDV) have been characterized. Analysis of growth kinetics for a pair of cytopathogenic (cp) and noncytopathogenic (ncp) strains revealed that ncp strain synthesized viral RNA at much reduced level compared to the cp strain. Kinetics of translation and replication, the effects of bi-cistronic versus mono-cistronic genomes, and cis requirements for viral replication were also examined in a BVDV replicon D19c. Importantly, our results suggest a tight regulation and a switch from translation to replication, and demonstrated the cis requirements of NS4B and NS5A in replication.

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Year:  2001        PMID： 11724267     DOI： 10.1023/a:1011836003128

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  22 in total

1.  Interactions of viral protein 3CD and poly(rC) binding protein with the 5' untranslated region of the poliovirus genome.

Authors:  A V Gamarnik; R Andino
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

2.  Correlation between point mutations in NS2 and the viability and cytopathogenicity of Bovine viral diarrhea virus strain Oregon analyzed with an infectious cDNA clone.

Authors:  B M Kümmerer; G Meyers
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

Review 3.  Molecular characterization of pestiviruses.

Authors:  G Meyers; H J Thiel
Journal:  Adv Virus Res       Date:  1996       Impact factor: 9.937

4.  Characterization of an autonomous subgenomic pestivirus RNA replicon.

Authors:  S E Behrens; C W Grassmann; H J Thiel; G Meyers; N Tautz
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103

5.  Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs.

Authors:  G Meyers; N Tautz; P Becher; H J Thiel; B M Kümmerer
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

6.  Assignment of the multifunctional NS3 protein of bovine viral diarrhea virus during RNA replication: an in vivo and in vitro study.

Authors:  C W Grassmann; O Isken; S E Behrens
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

7.  Establishment and characterization of cytopathogenic and noncytopathogenic pestivirus replicons.

Authors:  N Tautz; T Harada; A Kaiser; G Rinck; S Behrens; H J Thiel
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

8.  Noncytopathic Sindbis virus RNA vectors for heterologous gene expression.

Authors:  E V Agapov; I Frolov; B D Lindenbach; B M Prágai; S Schlesinger; C M Rice
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

9.  cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5' nontranslated region chimeras.

Authors:  I Frolov; M S McBride; C M Rice
Journal:  RNA       Date:  1998-11       Impact factor: 4.942

10.  Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line.

Authors:  V Lohmann; F Körner; J Koch; U Herian; L Theilmann; R Bartenschlager
Journal:  Science       Date:  1999-07-02       Impact factor: 47.728
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  1 in total

1.  Topology of the membrane-associated hepatitis C virus protein NS4B.

Authors:  Marika Lundin; Magnus Monné; Anders Widell; Gunnar Von Heijne; Mats A A Persson
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103
  1 in total

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