Literature DB >> 1172183

Accessibility of the minor groove of DNA in chromatin to the binding of antibiotics netropsin and distamycin A.

A F Melnikova, A S Zasedatelev, A M Kolchinsky, G V Gursky, A L Zhuze, S L Grochovsky, A D Mirzabekov.   

Abstract

The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared with that of free DNA. The present results combined with our data on the methylation of chromatin with dimethylsulphate [3] strongly suggest that the minor groove of DNA in chromatin is not occupied by chromatin proteins.

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Year:  1975        PMID： 1172183     DOI： 10.1007/bf00357544

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  17 in total

1.  Interactions of the antibiotic, distamycin A, with native DNA and with synthetic duplex polydeoxyribonucleotides.

Authors:  A K. Krey; R G. Allison; F E. Hahn
Journal:  FEBS Lett       Date:  1973-01-01       Impact factor: 4.124

2.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

3.  The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline cesium chloride density gradients.

Authors:  J C Wang
Journal:  J Mol Biol       Date:  1974-11-15       Impact factor: 5.469

4.  Binding of netropsin to DNA and synthetic polynucleotides.

Authors:  A S Zasedatelev; G V Gursky; C Zimmer; H Thrum
Journal:  Mol Biol Rep       Date:  1974-03       Impact factor: 2.316

5.  Localization of chromatin proteins within DNA grooves by methylation of chromatin with dimethyl sulphate.

Authors:  A D Mirzabekov; A F Melnikova
Journal:  Mol Biol Rep       Date:  1974-09       Impact factor: 2.316

6.  Binding of analogues of the antibiotics distamycin A and netropsin to native DNA. Effect of chomophore systems and basic residues of the oligopeptides on thermal stability, conformation and template activity of the DNA complexes.

Authors:  C Zimmer; G Luck; H Thrum; C Pitra
Journal:  Eur J Biochem       Date:  1972-03-15

7.  Interaction of a repotter molecule with chromatin. Evidence suggesting that the proteins of chromatin do not occupy the minor groove of deoxyribonucleic acid.

Authors:  R T Simpson
Journal:  Biochemistry       Date:  1970-11-24       Impact factor: 3.162

8.  Chromosomal ribonucleic acid of rat ascites cells.

Authors:  M E Dahmus; D J McConnell
Journal:  Biochemistry       Date:  1969-04       Impact factor: 3.162

9.  Template properties of liver chromatin.

Authors:  K Marushige; J Bonner
Journal:  J Mol Biol       Date:  1966-01       Impact factor: 5.469

10.  Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.

Authors:  G Luck; H Triebel; M Waring; C Zimmer
Journal:  Nucleic Acids Res       Date:  1974-03       Impact factor: 16.971
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  2 in total

1.  Preferential DNA photocleavage potency of Zn(II) over Ni(II) derivatives of carboxymethyl tetracationic porphyrin: the role of the mode of binding to DNA.

Authors:  Oxana A Kovaleva; Vladimir B Tsvetkov; Olga K Mamaeva; Valentina A Ol'shevskaya; Anton V Makarenkov; Lyubov G Dezhenkova; Alexander S Semeikin; Olga F Borisova; Alexander A Shtil; Anna K Shchyolkina; Dmitry N Kaluzhny
Journal:  Eur Biophys J       Date:  2014-08-28       Impact factor: 1.733

Review 2.  Targeting Transcription Factors for Cancer Treatment.

Authors:  Mélanie Lambert; Samy Jambon; Sabine Depauw; Marie-Hélène David-Cordonnier
Journal:  Molecules       Date:  2018-06-19       Impact factor: 4.411
  2 in total

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