X Zhao1, M Bassirat, K Zeinab, R D Helme. 1. Department of Laboratory Medicine, Beijing Hospital, Beijing 100730, China. linzhao@public.bta.net.cn
Abstract
OBJECTIVE: To study the effect of diabetes on the creatine kinase (CK) activity in different tissues of streptozotocin-induced diabetic rats. METHODS: Serum samples, heart, extensor digitorum longus, brain and bladder were collected from both streptozotocin-induced diabetic rat and control group. Ck was measured by enzymologic method. RESULTS: The body weight, heart weight and brain weight were reduced significantly compared with control group (P < 0.001), but bladder weight was increased significantly (P < 0.001). CK activity in serum and extensor digitorum longus in diabetic rat was significantly lower (P < 0.001); CK activity in diabetic heart was lower (P < 0.01); and in brain also lower (P < 0.05). A higher CK activity in diabetic bladder was found (P < 0.001). CONCLUSIONS: Diabetes can result in a lower CK activity in serum, heart, brain and extensor digitorum longus that may affect the energy metabolism in the tissues. A higher CK activity in diabetic bladder may reflect a functional compensatory mechanism.
OBJECTIVE: To study the effect of diabetes on the creatine kinase (CK) activity in different tissues of streptozotocin-induced diabeticrats. METHODS: Serum samples, heart, extensor digitorum longus, brain and bladder were collected from both streptozotocin-induced diabeticrat and control group. Ck was measured by enzymologic method. RESULTS: The body weight, heart weight and brain weight were reduced significantly compared with control group (P < 0.001), but bladder weight was increased significantly (P < 0.001). CK activity in serum and extensor digitorum longus in diabeticrat was significantly lower (P < 0.001); CK activity in diabetic heart was lower (P < 0.01); and in brain also lower (P < 0.05). A higher CK activity in diabetic bladder was found (P < 0.001). CONCLUSIONS:Diabetes can result in a lower CK activity in serum, heart, brain and extensor digitorum longus that may affect the energy metabolism in the tissues. A higher CK activity in diabetic bladder may reflect a functional compensatory mechanism.
Authors: Kayla Raider; Delin Ma; Janna L Harris; Isabella Fuentes; Robert S Rogers; Joshua L Wheatley; Paige C Geiger; Hung-Wen Yeh; In-Young Choi; William M Brooks; John A Stanford Journal: Neurochem Int Date: 2016-04-26 Impact factor: 3.921
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