Literature DB >> 11720863

Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.

S Padmanabhan1, R C Lavin, P M Thakker, J Guo, L Zhang, D Moore, M E Perlman, C Kirk, D Daly, K J Burke-Howie, T Wolcott, S Chari, D Berlove, J B Fischer, W F Holt, G J Durant, R N McBurney.   

Abstract

Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.

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Year:  2001        PMID: 11720863     DOI: 10.1016/s0960-894x(01)00644-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Preparation of Mono-Cbz Protected Guanidines.

Authors:  Kihyeok Kwon; Travis J Haussener; Ryan E Looper
Journal:  Organic Synth       Date:  2015

2.  Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines.

Authors:  Ryan E Looper; Travis J Haussener; James B C Mack
Journal:  J Org Chem       Date:  2011-07-19       Impact factor: 4.354

Review 3.  Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media.

Authors:  Zahra Khademi; Kobra Nikoofar
Journal:  RSC Adv       Date:  2020-08-17       Impact factor: 4.036

  3 in total

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