Literature DB >> 11720855

Synthesis and anti-HIV activity of oleanolic acid derivatives.

Y M Zhu1, J K Shen, H K Wang, L M Cosentino, K H Lee.   

Abstract

Thirteen oleanolic acid derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Saturating the C(12)-C(13) double bond and converting the C(17)-carboxyl group to an aminomethyl group led to compounds 13-15 and 19-20, respectively, which showed improved anti-HIV activity. Compound 15 was the most potent derivative with EC(50)=0.0039 microg/mL and TI=3570.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11720855     DOI： 10.1016/s0960-894x(01)00647-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Anti-inflammatory effects of oleanolic acid on LPS-induced inflammation in vitro and in vivo.

Authors:  Wonhwa Lee; Eun-Ju Yang; Sae-Kwang Ku; Kyung-Sik Song; Jong-Sup Bae
Journal:  Inflammation       Date:  2013-02       Impact factor: 4.092

2.  Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes.

Authors:  Mohamed Shaaban; Howaida I Abd-Alla; Amal Z Hassan; Hanan F Aly; Mohamed A Ghani
Journal:  Org Med Chem Lett       Date:  2012-08-16

3.  Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives.

Authors:  Jorge A R Salvador; Vânia M Moreira; Rui M A Pinto; Ana S Leal; José A Paixão
Journal:  Beilstein J Org Chem       Date:  2012-01-30       Impact factor: 2.883

Review 4.  Recent advances in synthesis and biological activity of triterpenic acylated oximes.

Authors:  Barbara Bednarczyk-Cwynar; Lucjusz Zaprutko
Journal:  Phytochem Rev       Date:  2014-04-11       Impact factor: 5.374

5.  Hyaluronidase Inhibitory Activity of Pentacylic Triterpenoids from Prismatomeris tetrandra (Roxb.) K. Schum: Isolation, Synthesis and QSAR Study.

Authors:  Nor Hayati Abdullah; Noel Francis Thomas; Yasodha Sivasothy; Vannajan Sanghiran Lee; Sook Yee Liew; Ibrahim Ali Noorbatcha; Khalijah Awang
Journal:  Int J Mol Sci       Date:  2016-02-14       Impact factor: 5.923

6.  Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties.

Authors:  Sibusiso Rali; Opeoluwa O Oyedeji; Olukayode O Aremu; Adebola O Oyedeji; Benedicta N Nkeh-Chungag
Journal:  Mediators Inflamm       Date:  2016-06-13       Impact factor: 4.711

Review 7.  Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?

Authors:  Kaitlind C Howard; Octavio A Gonzalez; Sylvie Garneau-Tsodikova
Journal:  RSC Med Chem       Date:  2021-02-26

8.  Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate.

Authors:  Raya Soltane; Amani Chrouda; Ahmed Mostafa; Ahmed A Al-Karmalawy; Karim Chouaïb; Abdelwaheb Dhahri; Rami Adel Pashameah; Ahlam Alasiri; Omnia Kutkat; Mahmoud Shehata; Hichem Ben Jannet; Jawhar Gharbi; Mohamed A Ali
Journal:  Pathogens       Date:  2021-05-19

9.  In silico and in vivo anti-malarial studies of 18β glycyrrhetinic acid from Glycyrrhiza glabra.

Authors:  Komal Kalani; Jyoti Agarwal; Sarfaraz Alam; Feroz Khan; Anirban Pal; Santosh Kumar Srivastava
Journal:  PLoS One       Date:  2013-09-24       Impact factor: 3.240

Review 10.  Antiviral Activities of Oleanolic Acid and Its Analogues.

Authors:  Vuyolwethu Khwaza; Opeoluwa O Oyedeji; Blessing A Aderibigbe
Journal:  Molecules       Date:  2018-09-09       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.