| Literature DB >> 11720852 |
D Kim1, L Wang, C G Caldwell, P Chen, P E Finke, B Oates, M MacCoss, S G Mills, L Malkowitz, S L Gould, J A DeMartino, M S Springer, D Hazuda, M Miller, J Kessler, R Danzeisen, G Carver, A Carella, K Holmes, J Lineberger, W A Schleif, E A Emini.
Abstract
Replacement of the large hydantoin-indole moiety from our previous work with a variety of smaller heterocyclic analogues gave rise to potent CCR5 antagonists having binding affinity comparable to the hydantoin analogues. The synthesis, SAR, and biological profiles of this class of antagonists are described.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11720852 DOI： 10.1016/s0960-894x(01)00655-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823