Literature DB >> 11720851

Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.

D Kim1, L Wang, C G Caldwell, P Chen, P E Finke, B Oates, M MacCoss, S G Mills, L Malkowitz, S L Gould, J A DeMartino, M S Springer, D Hazuda, M Miller, J Kessler, R Danzeisen, G Carver, A Carella, K Holmes, J Lineberger, W A Schleif, E A Emini.   

Abstract

A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.

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Year:  2001        PMID: 11720851     DOI: 10.1016/s0960-894x(01)00654-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

1.  Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance.

Authors:  Malavika S Giri; Michael Nebozyhn; Andrea Raymond; Bethsebah Gekonge; Aidan Hancock; Shenoa Creer; Calen Nicols; Malik Yousef; Andrea S Foulkes; Karam Mounzer; Jane Shull; Guido Silvestri; Jay Kostman; Ronald G Collman; Louise Showe; Luis J Montaner
Journal:  J Immunol       Date:  2009-04-01       Impact factor: 5.422

Review 2.  HIV entry inhibitors and their potential in HIV therapy.

Authors:  Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2009-03       Impact factor: 12.944

3.  Discovery of Novel CCR5 Ligands as Anticolorectal Cancer Agents by Sequential Virtual Screening.

Authors:  Mariam A El-Zohairy; Darius P Zlotos; Martin R Berger; Hassan H Adwan; Yasmine M Mandour
Journal:  ACS Omega       Date:  2021-04-16

4.  Synthesis and in vitro activity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line.

Authors:  Petja Marinova; Marin Marinov; Maria Kazakova; Yana Feodorova; Plamen Penchev; Victoria Sarafian; Neyko Stoyanov
Journal:  Biotechnol Biotechnol Equip       Date:  2014-07-10       Impact factor: 1.632

Review 5.  The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity.

Authors:  Martin Kalník; Peter Gabko; Maroš Bella; Miroslav Koóš
Journal:  Molecules       Date:  2021-06-30       Impact factor: 4.411

  5 in total

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