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Literature DB >> 11720850

Flavonoids: structural requirements for antiproliferative activity on breast cancer cells.

C Pouget¹, F Lauthier, A Simon, C Fagnere, J P Basly, C Delage, A J Chulia.

Abstract

Several classes of flavonoids (flavones, flavanones, 2'-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure-activity relationships of these compounds were discussed. 2'-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.

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Year: 2001 PMID： 11720850 DOI： 10.1016/s0960-894x(01)00617-5

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

25 in total

1. Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones.

Authors: Thomas Walle; Nga Ta; Toshihiko Kawamori; Xia Wen; Petra A Tsuji; U Kristina Walle
Journal: Biochem Pharmacol Date: 2006-12-28 Impact factor: 5.858

2. Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.

Authors: Kevin Bonfield; Erica Amato; Tony Bankemper; Hannah Agard; Jeffrey Steller; James M Keeler; David Roy; Adam McCallum; Stefan Paula; Lili Ma
Journal: Bioorg Med Chem Date: 2012-02-27 Impact factor: 3.641

3. Effects of humic acids in vitro.

Authors: Janka Vašková; Beáta Veliká; Martina Pilátová; Ivan Kron; Ladislav Vaško
Journal: In Vitro Cell Dev Biol Anim Date: 2011-04-13 Impact factor: 2.416

4. 2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.

Authors: Yuqing Sheng; Mingchang Zou; Yan Wang; Qiheng Li
Journal: Oncol Lett Date: 2015-10-12 Impact factor: 2.967

5. Caspase-dependent apoptosis induced by two synthetic halogenated flavanones, 3',7-dichloroflavanone and 3',6-dichloroflavanone, on human breast and prostate cancer cells.

Authors: Maliheh Safavi; Raheleh Shakeri; Sussan Kabudanian Ardestani; Jamshid Davoodi; Soheila Ajdary; Alireza Foroumadi
Journal: In Vitro Cell Dev Biol Anim Date: 2017-12-20 Impact factor: 2.416

Flavonoids: structural requirements for antiproliferative activity on breast cancer cells.

1. Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones.

2. Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.

3. Effects of humic acids in vitro.

4. 2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.

5. Caspase-dependent apoptosis induced by two synthetic halogenated flavanones, 3',7-dichloroflavanone and 3',6-dichloroflavanone, on human breast and prostate cancer cells.

6. Synthesis and aromatase inhibitory activity of flavanones.

Review 7. Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?

8. Pharmacophore mapping of flavone derivatives for aromatase inhibition.

Review 9. Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.

10. 7-Meth-oxy-2-phenyl-chroman-4-one.