Literature DB >> 11719989

TT dinucleotides containing an isoxazoline moiety: synthesis and binding affinity study.

J R Kong1, S K Kim, B J Moon, S J Kim, B H Kim.   

Abstract

We have prepared four diastereomers of TT dinucleotides containing an isoxazoline moiety and four dodecanucleotides incorporating these TT dinucleotides in the middle of the DNA sequence. We also have determined the melting temperatures of these modified oligonucleotides (Tm values) by measuring change in UV absorbance.

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Year:  2001        PMID: 11719989     DOI: 10.1081/NCN-100107187

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  Synthesis of 5-isoxazol-5-yl-2'-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.

Authors:  Yoon-Suk Lee; Sun Min Park; Byeang Hyean Kim
Journal:  Bioorg Med Chem Lett       Date:  2008-12-31       Impact factor: 2.823

  1 in total

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