Literature DB >> 11719182

A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst.

K Nishikura1.   

Abstract

One of the many intriguing features of gene silencing by RNA interference is the apparent catalytic nature of the phenomenon. New biochemical and genetic evidence now shows that an RNA-directed RNA polymerase chain reaction, primed by siRNA, amplifies the interference caused by a small amount of "trigger" dsRNA.

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Year:  2001        PMID： 11719182     DOI： 10.1016/s0092-8674(01)00581-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  53 in total

1.  Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.

Authors:  Dun Yang; Frank Buchholz; Zhongdong Huang; Andrei Goga; Chih-Ying Chen; Frances M Brodsky; J Michael Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-02       Impact factor: 11.205

2.  Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing.

Authors:  Alicia M Celotto; Brenton R Graveley
Journal:  RNA       Date:  2002-06       Impact factor: 4.942

3.  RNA target sequences promote spreading of RNA silencing.

Authors:  Helena Van Houdt; Annick Bleys; Anna Depicker
Journal:  Plant Physiol       Date:  2003-01       Impact factor: 8.340

Review 4.  RNA interference: from an ancient mechanism to a state of the art therapeutic application?

Authors:  Christoph Arenz; Ute Schepers
Journal:  Naturwissenschaften       Date:  2003-07-23

5.  siRNA function in RNAi: a chemical modification analysis.

Authors:  Ya-Lin Chiu; Tariq M Rana
Journal:  RNA       Date:  2003-09       Impact factor: 4.942

6.  Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces?

Authors:  Anatoly P Gmyl; Sergey A Korshenko; Evegny V Belousov; Elena V Khitrina; Vadim I Agol
Journal:  RNA       Date:  2003-10       Impact factor: 4.942

7.  RNA recombination in vivo in the absence of viral replication.

Authors:  Andreas Gallei; Alexander Pankraz; Heinz-Jürgen Thiel; Paul Becher
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

8.  ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells.

Authors:  Weidong Yang; Qingde Wang; Kelly L Howell; Joshua T Lee; Dan-Sung C Cho; John M Murray; Kazuko Nishikura
Journal:  J Biol Chem       Date:  2004-11-19       Impact factor: 5.157

9.  Dampening the silencing effect of RNA interference in mammals.

Authors:  Junlong Zhang
Journal:  Biochem J       Date:  2005-09-15       Impact factor: 3.857

10.  Differential gene silencing induced by short interfering RNA in cultured pine cells associates with the cell cycle phase.

Authors:  Wei Tang; Ronald J Newton; Douglas A Weidner
Journal:  Planta       Date:  2005-12-09       Impact factor: 4.116
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