Literature DB >> 11718878

The sleep switch: hypothalamic control of sleep and wakefulness.

C B Saper1, T C Chou, T E Scammell.   

Abstract

More than 70 years ago, von Economo predicted a wake-promoting area in the posterior hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have dramatically confirmed these predictions. The ventrolateral preoptic nucleus contains GABAergic and galaninergic neurons that are active during sleep and are necessary for normal sleep. The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed in which wake- and sleep-promoting neurons inhibit each other, which results in stable wakefulness and sleep. Disruption of wake- or sleep-promoting pathways results in behavioral state instability.

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Year:  2001        PMID： 11718878     DOI： 10.1016/s0166-2236(00)02002-6

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  366 in total

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2.  Electrophysiological Properties of Genetically Identified Histaminergic Neurons.

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Review 4.  Sleep and circadian rhythms: do sleep centers talk back to the clock?

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Journal:  Nat Neurosci       Date:  2003-10       Impact factor: 24.884

5.  Sleep-waking discharge patterns of median preoptic nucleus neurons in rats.

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6.  Suppression subtractive hybridization and microarray identification of estrogen-regulated hypothalamic genes.

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Journal:  Neurochem Res       Date:  2004-06       Impact factor: 3.996

Review 7.  Sex differences in circadian timing systems: implications for disease.

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Journal:  Front Neuroendocrinol       Date:  2013-11-25       Impact factor: 8.606

8.  The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta.

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Journal:  J Comp Neurol       Date:  2009-04-20       Impact factor: 3.215

9.  The ontogeny of mammalian sleep: a response to Frank and Heller (2003).

Authors:  Mark S Blumberg; Karl A E Karlsson; Adele M H Seelke; Ethan J Mohns
Journal:  J Sleep Res       Date:  2005-03       Impact factor: 3.981

Review 10.  Trazodone for Insomnia: A Systematic Review.

Authors:  Karim Yahia Jaffer; Tiffany Chang; Brigitte Vanle; Jonathan Dang; Alexander J Steiner; Natalie Loera; Marina Abdelmesseh; Itai Danovitch; Waguih William Ishak
Journal:  Innov Clin Neurosci       Date:  2017-08-01
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