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Literature DB >> 11718875

Viral-based gene transfer to the mammalian CNS for functional genomic studies.

C G Janson¹, S W McPhee, P Leone, A Freese, M J During.

Abstract

A fundamental problem in neuroscience has been the creation of suitable in vivo model systems to study basic neurological phenomena and pathology of the central nervous system (CNS). Somatic cell genetic engineering with viral vectors provides a versatile tool to model normal brain physiology and a variety of neurological diseases.

Entities: Disease Species

Mesh：

Year: 2001 PMID： 11718875 DOI： 10.1016/s0166-2236(00)01954-8

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

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Cited

12 in total

1. Gene therapy in epilepsy.

Authors: Annamaria Vezzani
Journal: Epilepsy Curr Date: 2004 May-Jun Impact factor: 7.500

2. Screen for dominant behavioral mutations caused by genomic insertion of P-element transposons in Drosophila: an examination of the integration of viral vector sequences.

Authors: Lyle E Fox; David Green; Ziying Yan; John F Engelhardt; Chun-Fang Wu
Journal: J Neurogenet Date: 2007 Jan-Jun Impact factor: 1.250

3. Comparison of Endovascular and Intraventricular Gene Therapy With Adeno-Associated Virus-α-L-Iduronidase for Hurler Disease.

Authors: Christopher G Janson; Liudmila G Romanova; Paola Leone; Zhenhong Nan; Lalitha Belur; R Scott McIvor; Walter C Low
Journal: Neurosurgery Date: 2014-01 Impact factor: 4.654

Review 4. Animal models of limbic epilepsies: what can they tell us?

Authors: Douglas A Coulter; Dan C McIntyre; Wolfgang Löscher
Journal: Brain Pathol Date: 2002-04 Impact factor: 6.508

5. AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease.

Authors: Nicholas R Franich; Helen L Fitzsimons; Dahna M Fong; Matthias Klugmann; Matthew J During; Deborah Young
Journal: Mol Ther Date: 2008-03-25 Impact factor: 11.454

Viral-based gene transfer to the mammalian CNS for functional genomic studies.

1. Gene therapy in epilepsy.

2. Screen for dominant behavioral mutations caused by genomic insertion of P-element transposons in Drosophila: an examination of the integration of viral vector sequences.

3. Comparison of Endovascular and Intraventricular Gene Therapy With Adeno-Associated Virus-α-L-Iduronidase for Hurler Disease.

Review 4. Animal models of limbic epilepsies: what can they tell us?

5. AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease.

6. Sonoporation-mediated gene transfer into adult rat dorsal root ganglion cells.

7. High-efficiency transient transduction of human embryonic stem cell-derived neurons with baculoviral vectors.

8. Animal models for the development of new neuropharmacological therapeutics in the status epilepticus.

9. Functional protein delivery into neurons using polymeric nanoparticles.

10. Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning.