Uncertainty analysis for temperature prediction of biological bodies subject to randomly spatial heating.

An analytical solution to the Pennes bioheat transfer equation in three-dimensional geometry with practical hyperthermia boundary conditions and random heating was obtained in this paper. Uncertainties for the predicted temperatures of tissues due to approximate parameters were studied based on analyzing one-dimensional heat transfer in the biological bodies subject to a spatially decay heating. Contributions from each of the thermal parameters such as heat conductivity, blood perfusion rate, and metabolic rate of the tissues, the scattering coefficient and the surface power flux of the heating apparatus were compared and the uncertainty limit for temperature distribution in this case was estimated. The results are useful in a variety of clinical hyperthermia and biological thermal parameter measurement.