Literature DB >> 11716829

Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA.

M Shimada1, K Yoshinari, E Tanabe, E Shimakawa, M Kobashi, K Nagata, Y Yamazoe.   

Abstract

A hydroxysteroid sulfotransferase (ST2A1) was identified as a form mediating neurosteroid sulfation in rat brain. The sole expression among known rat ST2A forms was indicated by brain RT-PCR. All nucleotide sequences of seven ST2A cDNA clones isolated from brain matched completely with that of hepatic ST2A1. The recombinant ST2A1 protein mediated neurosteroid sulfation. These data strongly suggest a functional role of ST2A1 as a neurosteroid sulfotransferase in rat brain.

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Year:  2001        PMID： 11716829     DOI： 10.1016/s0006-8993(01)03061-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

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  6 in total

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