Literature DB >> 11716535

Cyclin-mediated export of human Orc1.

H Laman1, G Peters, N Jones.   

Abstract

Viral cyclin/cdk6 complexes interact with and phosphorylate human Orc1, a component of the origin recognition complex (ORC) that functions in DNA replication. Here we assess the effect that viral cyclin has on the intracellular location of human Orc1, which is present in both nuclear and cytoplasmic pools. Overexpression of K cyclin or cyclin A results in Crm1-dependent export of Orc1 to the cytoplasm, and this process is dependent on the phosphorylation status of several cdk target sites in Orc1. These findings support a model where S phase promoting cyclin activity drives the export of a component of replication complexes.

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Year:  2001        PMID： 11716535     DOI： 10.1006/excr.2001.5360

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  9 in total

1.  Characterization of a novel origin recognition complex-like complex: implications for DNA recognition, cell cycle control, and locus-specific gene amplification.

Authors:  Mohammad Mohammad; Randall D York; Jonathan Hommel; Geoffrey M Kapler
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

2.  Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites.

Authors:  Alan M Moses; Muluye E Liku; Joachim J Li; Richard Durbin
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-31       Impact factor: 11.205

3.  Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis.

Authors:  Tapas Saha; Soma Ghosh; Alex Vassilev; Melvin L DePamphilis
Journal:  J Cell Sci       Date:  2006-03-14       Impact factor: 5.285

Review 4.  Cell cycle regulation during viral infection.

Authors:  Sumedha Bagga; Michael J Bouchard
Journal:  Methods Mol Biol       Date:  2014

5.  Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition.

Authors:  Maria Emanuela Cuomo; Georgina M Platt; Laurence H Pearl; Sibylle Mittnacht
Journal:  J Biol Chem       Date:  2011-01-13       Impact factor: 5.157

6.  Phosphorylation of ORC2 protein dissociates origin recognition complex from chromatin and replication origins.

Authors:  Kyung Yong Lee; Sung Woong Bang; Sang Wook Yoon; Seung-Hoon Lee; Jong-Bok Yoon; Deog Su Hwang
Journal:  J Biol Chem       Date:  2012-02-13       Impact factor: 5.157

7.  An autonomous replicating element within the KSHV genome.

Authors:  Subhash C Verma; Ke Lan; Tathagata Choudhuri; Murray A Cotter; Erle S Robertson
Journal:  Cell Host Microbe       Date:  2007-08-16       Impact factor: 21.023

8.  Orc1 controls centriole and centrosome copy number in human cells.

Authors:  Adriana S Hemerly; Supriya G Prasanth; Khalid Siddiqui; Bruce Stillman
Journal:  Science       Date:  2009-02-06       Impact factor: 47.728

9.  Characterizing the normal proteome of human ciliary body.

Authors:  Renu Goel; Krishna R Murthy; Srinivas M Srikanth; Sneha M Pinto; Mitali Bhattacharjee; Dhanashree S Kelkar; Anil K Madugundu; Gourav Dey; Sujatha S Mohan; Venkatarangaiah Krishna; Ts Keshava Prasad; Shukti Chakravarti; H C Harsha; Akhilesh Pandey
Journal:  Clin Proteomics       Date:  2013-08-01       Impact factor: 3.988
  9 in total

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