Literature DB >> 11715046

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

B Geiger1, A Bershadsky, R Pankov, K M Yamada.   

Abstract

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.

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Year:  2001        PMID： 11715046     DOI： 10.1038/35099066

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  665 in total

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9.  Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells.

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