| Literature DB >> 11715016 |
A A Alcasabas1, A J Osborn, J Bachant, F Hu, P J Werler, K Bousset, K Furuya, J F Diffley, A M Carr, S J Elledge.
Abstract
Cells experiencing DNA replication stress activate a response pathway that delays entry into mitosis and promotes DNA repair and completion of DNA replication. The protein kinases ScRad53 and SpCds1 (in baker's and fission yeast, respectively) are central to this pathway. We describe a conserved protein Mrc1, mediator of the replication checkpoint, required for activation of ScRad53 and SpCds1 during replication stress. mrc1 mutants are sensitive to hydroxyurea and have a checkpoint defect similar to rad53 and cds1 mutants. Mrc1 may be the replicative counterpart of Rad9 and Crb2, which are required for activating ScRad53 and Chk1 in response to DNA damage.Entities:
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Year: 2001 PMID： 11715016 DOI： 10.1038/ncb1101-958
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824