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Literature DB >> 11714936

Podophyllin office therapy against condyloma should be abandoned.

Abstract

Podophyllin, a crude plant extract with low efficacy, high toxicity, and a serious mutagenicity profile does not comply with the WHO guidelines for plant derived treatments and should be removed from clinical treatment protocols. Home treatment with pharmaceutical products based on podophyllotoxin-the purified, standardised active antiwart ingredient of podophyllin-represents safe and effective first line therapy for patients with anogenital warts.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2001 PMID： 11714936 PMCID： PMC1744412 DOI： 10.1136/sti.77.6.409

Source DB: PubMed Journal: Sex Transm Infect ISSN： 1368-4973 Impact factor: 3.519

27 in total

1. The management and prevention of premalignant penile lesions.

Authors: G von Krogh; S Horenblas
Journal: Scand J Urol Nephrol Suppl Date: 2000

2. The biological effects and the chemical composition of podophyllin: a review.

Authors: M KELLY; J L HARTWELL
Journal: J Natl Cancer Inst Date: 1954-02 Impact factor: 13.506

3. Spontaneous tumors in C3H-A vy and C3H-A vy fB mice: high incidence in the United States and low incidence in Australia.

Authors: J R Sabine; B J Horton; M B Wicks
Journal: J Natl Cancer Inst Date: 1973-05 Impact factor: 13.506

Review 4. The metaphase-arresting plant alkaloids and cancer chemotherapy.

Authors: H Savel
Journal: Prog Exp Tumor Res Date: 1966

5. Podophyllotoxin for condylomata acuminata eradication. Clinical and experimental comparative studies on Podophyllum lignans, colchicine and 5-fluorouracil.

Authors: G von Krogh
Journal: Acta Derm Venereol Suppl (Stockh) Date: 1981

6. Podophyllotoxin in serum: absorption subsequent to three-day repeated applications of a 0.5% ethanolic preparation on condylomata acuminata.

Authors: G von Krogh
Journal: Sex Transm Dis Date: 1982 Jan-Mar Impact factor: 2.830

7. Mutagenic activity of quercetin and related compounds.

Authors: L F Bjeldanes; G W Chang
Journal: Science Date: 1977-08-05 Impact factor: 47.728

8. Neurologic manifestations of podophyllin toxicity.

Authors: C M Filley; N R Graff-Richard; J R Lacy; M A Heitner; M P Earnest
Journal: Neurology Date: 1982-03 Impact factor: 9.910

9. Penile condylomata acuminata: an experimental model for evaluation of topical self-treatment with 0.5--1.0% ethanolic preparations of podophyllotoxin for three days.

Authors: G von Krogh
Journal: Sex Transm Dis Date: 1981 Jul-Sep Impact factor: 2.830

10. Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum).

Authors: A M Pamukcu; S Yalçiner; J F Hatcher; G T Bryan
Journal: Cancer Res Date: 1980-10 Impact factor: 12.701

5 in total

1. Genital warts: a comprehensive review.

Authors: Valerie R Yanofsky; Rita V Patel; Gary Goldenberg
Journal: J Clin Aesthet Dermatol Date: 2012-06

Review 2. An armamentarium of wart treatments.

Authors: Michelle M Lipke
Journal: Clin Med Res Date: 2006-12

3. Association Between Fetal Safety Outcomes and Exposure to Local Podophyllotoxin During Pregnancy.

Authors: Niklas Worm Andersson; Jon Trærup Andersen
Journal: JAMA Dermatol Date: 2020-03-01 Impact factor: 10.282

4. A Comparative Study of Liquid Nitrogen Cryotherapy as Monotherapy versus in Combination with Podophyllin in the Treatment of Condyloma Acuminata.

Authors: Nidhi Sharma; Sanjeev Sharma; Chetna Singhal
Journal: J Clin Diagn Res Date: 2017-03-01

5. Podophyllotoxin Exposure Affects Organelle Distribution and Functions in Mouse Oocyte Meiosis.

Authors: Ping-Shuang Lu; Lan-Ping Xie; Xiao-Han Kong; Yi Xu; Shao-Chen Sun
Journal: Front Cell Dev Biol Date: 2021-05-19

5 in total