| Literature DB >> 11714613 |
N H Nam1, Y Kim, Y J You, D H Hong, H M Kim, B Z Ahn.
Abstract
Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.Entities:
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Year: 2001 PMID： 11714613 DOI： 10.1016/s0960-894x(01)00622-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823