| Literature DB >> 11714610 |
C S Jeung1, J B Song, Y H Kim, J Suh.
Abstract
To design artificial restriction enzymes, synthetic catalytic centers that effectively hydrolyze linear double-stranded polydeoxyribonucleotides are needed. The Co(III) complex of cyclen (CoCyc) attached to polystyrene derivatives hydrolyzes linearized pUC18 DNA with half-lives as short as 30 min at 25 degrees C. The catalytic activity of CoCyc is enhanced by >150 times on attachment to the resin.Entities:
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Year: 2001 PMID： 11714610 DOI： 10.1016/s0960-894x(01)00615-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823