| Literature DB >> 11714607 |
Y Mikata1, Y Shinohara, K Yoneda, Y Nakamura, I Brudziñska, T Tanase, T Kitayama, R Takagi, T Okamoto, I Kinoshita, M Doe, C Orvig, S Yano.
Abstract
Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes.Entities:
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Year: 2001 PMID： 11714607 DOI： 10.1016/s0960-894x(01)00623-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823