| Literature DB >> 11714601 |
G Müller1, M Albers, R Fischer, G Hessler, T E Lehmann, H Okigami, M Tajimi, K Bacon, T Rölle.
Abstract
Piperidinyl carboxylic acid-based derivatives were prepared as antagonists of the leukocyte cell adhesion process that is mediated through the interaction of the alpha(4)beta(1) integrin (VLA-4, very late antigen 4) and the vascular cell adhesion molecule 1 (VCAM-1). Compounds 2a-h inhibited the adhesion in a cell-based assay in the low and sub micromolar range, a pharmacokinetic study of 2d is reported.Entities:
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Year: 2001 PMID： 11714601 DOI： 10.1016/s0960-894x(01)00613-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823